Pharmacy 8030

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Contents

Objectives

  1. Learn drug metabolism with game show "battle" on Tuesday, October 24th, 2017.
    • Types, Cofactors and Reactions of oxidative and reductive drug metabolizing enzymes.
    • Types, Cofactors and Reactions of conjugating drug metabolizing enzymes.
  2. Drug design workshop on Thursday, October 26th, 2017.
    • How and what is reaction phenotyping?
    • How do you determine the metabolism sites for an arbitrary drug?
    • How do you design drugs with desirable drug metabolizing properties

Scoring for My Part (50 Foo-foo Points)

  1. Drug Metabolism Battle Tuesday, November 13th (25 Foo-foo Points)
    • Scoring = 25 Foo-foo *0.5 + 25 Foo-foo * 0.5*(Your Team's Score/Team with Highest Score)
    • Minimum Score Possible = 50%
    • Maximum Score Possible = 100%
  2. Drug Design Workshop Thursday, November 15th (25 Foo-foo Points)
    • Going to have a random person in your group present for each presentation.
      1. Reaction Phenotyping
      2. Sites of Metabolism
      3. Designing Drugs with Desirable Drug Metabolizing Properties
    • Assuming a total of 3 teams, your team will vote on which one of the teams did a better job.
      • For example, if you are on Team 2, you will vote on Team 1 and Team 3. If you are on Team 1, you will vote for Team 2 and Team 3.
    • Vote Ratio = Votes/(Max Possible Votes)
    • Scoring = 25 Foo-foo *0.5 + 25 Foo-foo * 0.5*(Vote Ratio/Max Vote Ratio)
  3. Score given to Dr. Xiaong: Your Team's Foo-foo points/50 Foo-foo points.

Step 1: Review the Lectures

  1. Drug Metabolism Battle on Tuesday, October 24th, 2017.
  2. Drug Design Workshop on Thursday, October 26th, 2017.
    • PowerPointIcon.pngLecture (pptx)
      • Updates: 10/22/16- Misspelled Title: Should be Drug Design Workshop
    • MovieIcon.png Drug Metabolism Workshop ~30 minutes
      • For those you with a short attention span, you can also watch the lecture slide-by-slide. You can also skip directly to the tutorials (below)

Step 2: Go through the Flash Cards for the Drug Metabolism Battle on Tuesday November 5th, 2019

Instructions

  • Desktop Computer: Space, Enter, Left and Right Arrows will allow you to progress through the flash cards.
  • Ipad, Android, Mobile Phone: Left and right swipe allowed.

Flash Cards

Step 3: Go through the Tutorials for the Drug Design Workshop on Thursday November 7th, 2019

  • If you do not know the login and password, email me.
  • If you get an access forbidden remark, go to Google and type "What is my IP address?" and send the IP address to me.

Drug Design Tutorials

All TutorialsLock.png
  • For the Lock.png, use the login and password that I sent you by email.
Individual Tutorials
  1. Tutorial on Reaction PhenotypingLock.png
  2. Tutorial on Determining the Sites of MetabolismLock.png
  3. Tutorial on Designing Drugs with Desirable Drug Metabolizing PropertiesLock.png

Thursday Project

  1. Reaction Phenotyping
  2. Determining the Sites of Metabolism
  3. Designing Drugs with Desirable Drug Metabolizing Properties